Jian Yang

About

Looking up, I observe the immensity of the cosmos; bowing my head, I examine the multitude of the world. Thus, I let my eyes wander and my mind roam freely, fully enjoying the pleasures of sight and sound—what a true delight it is! 仰观宇宙之大,俯察品类之盛,所以游目骋怀,足以极视听之娱,信可乐也。 Academic Profile Medical Doctor (M.D.), specializing in: Evolutionary genomics and comparative genomics to analyze adaptive evolution and neural regenerative capacity; Bioinformatics and patch-clamp neuroelectrophysiology to investigate spinal cord development patterns, molecular mechanisms, intrinsic regenerative pathways, and microenvironment reconstruction for spinal repair and functional recovery; Molecular mechanisms and therapeutic agents for neurodegenerative diseases in Parkinson’s models. Professional Experience Former Roles: First Research Assistant to Academician, Key Laboratory of Neuroregeneration, Ministry of Education, Jiangsu Province; Director of Bioinformatics and Patch-Clamp Electrophysiology Platform, Key Laboratory of Neuroregeneration (MOE); Experimentalist, NMPA Key Laboratory for Tissue Engineering Technology Products Research and Evaluation. Current: Neurologist, Neurological Disease Center, Deyang People’s Hospital Affiliated to Chengdu University of Traditional Chinese Medicine. Research Focus Long-term dedication to multi-omics integration (genomics, transcriptomics) combined with experimental validation to study: Neurodegenerative diseases (e.g., Parkinson’s pathology); Neural development and regenerative repair mechanisms; Spinal cord regeneration microenvironment reconstruction via bioinformatics and patch-clamp electrophysiology. Key Achievements Publications: 23 SCI-indexed papers with cumulative Impact Factor: 174.2 5 papers with IF > 10 (5-year impact factor); 6 CAS Zone 1 papers (5 TOP journals); 10 CAS Zone 2 papers (4 TOP journals); 19 JCR Q1 papers, 3 JCR Q2 papers. Research cited by Nature, Reuters, and Science and Technology Daily; Oxford University Press "Top 10% Read" award. Mentorship: Supervised 3 Ph.D. candidates (Nanjing University of Chinese Medicine & Jiangsu Provincial Hospital of Traditional Chinese Medicine); Guided 2 M.S. students (Neurobiology, Nantong University). Projects & Grants: Co-investigator: 3 NSFC General Projects; 1 NSFC Key Project (led by Academician); 1 Jiangsu Provincial Priority Academic Program; 1 Sichuan Provincial Key R&D Project. Principal Investigator: 1 Talent Project (Nantong University); 1 MOE Key Laboratory Project (Tongji University). Awards: First Prize, Huaxia Medical Science and Technology Award; Second Prize, Natural Science Award of MOE Higher Education Outstanding Research. Leadership & Service Director, Bioinformatics and Patch-Clamp Electrophysiology Platform, MOE Key Laboratory of Neuroregeneration; Experimentalist, NMPA Key Laboratory for Tissue Engineering; Founding Member: China Spinal Cord Injury Repair and Functional Reconstruction Alliance; CPAM Smart Healthcare and Intelligent Medicine Branch; Senior Member, Jiangsu Association for Science and Technology; Member, China Computer Federation (CCF); Mentor for Ph.D./M.S. candidates (NJUCM & Jiangsu Provincial Hospital); Lecturer, Bioinformatics Graduate Course, MOE Key Laboratory of Neuroregeneration (Nantong University); Review Expert: Research Equipment Bidding (Nantong University); Entrance Exam Designer for Tertiary Hospitals; First Research Assistant to Chinese Academy of Engineering Academician; Peer Reviewer for multiple SCI journals (awarded "Outstanding Reviewer").

Work

People's Hospital of Deyang City

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M.D.

China

Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education

China

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Education

Soochow University

China
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Doctor of Medicine(M.D.)

Nantong University

China
→
Master's degree

Publications

Convergent and divergent transcriptional reprogramming of motor and sensory neurons underlying response to peripheral nerve injury

Journal of Advanced Research

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Genome-wide profiling and functional characterization of circular RNAs in neural development and injury: insights from a rat model research

Cellular and Molecular Life Sciences

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VCF2Dis: an ultra-fast and efficient tool to calculate pairwise genetic distance and construct population phylogeny from VCF files

GigaScience

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Bilateral Thalamic Edema Caused by Tentorial Galenic Dural Arteriovenous Fistula and Sinus Thrombosis: Successful Endovascular Therapy

Turkish Neurosurgery

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Biomimetic-inspired piezoelectric ovalbumin/BaTiO3 scaffolds synergizing with anisotropic topology for modulating Schwann cell and DRG behavior

International Journal of Biological Macromolecules

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VCF2PCACluster: a simple, fast and memory-efficient tool for principal component analysis of tens of millions of SNPs

BMC Bioinformatics

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Cartilage stem/progenitor cells‐derived exosomes facilitate knee cartilage repair in a subacute osteoarthritis rat model

Journal of Cellular and Molecular Medicine

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Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect

Bioactive Materials

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Exosomes derived from primary cartilage stem/progenitor cells promote the repair of osteoarthritic chondrocytes by modulating immune responses

International Immunopharmacology

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Integrative mRNA and miRNA Expression Profiles from Developing Zebrafish Head Highlight Brain-Preference Genes and Regulatory Networks

Molecular Neurobiology

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NGenomeSyn: an easy-to-use and flexible tool for publication-ready visualization of syntenic relationships across multiple genomes

Bioinformatics

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Integrated analyses reveal evolutionarily conserved and specific injury response genes in dorsal root ganglion ( Article Type: Analysis)

Scientific Data

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Deciphering the dynamic niches and regeneration-associated transcriptional program of motoneurons following peripheral nerve injury

iScience

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Deciphering the dynamic niches and regeneration-associated transcriptional program of motoneurons following peripheral nerve injury

iScience

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Evolution of the ErbB gene family and analysis of regulators of Egfr expression during development of the rat spinal cord

Neural Regeneration Research

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Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord (Section: Tissue engineering)

Engineering

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Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury.

Experimental neurology

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Molecular Regulatory Mechanism and Toxicology of Neurodegenerative Processes in MPTP/Probenecid-Induced Progressive Parkinson’s Disease Mice Model Revealed by Transcriptome

Molecular Neurobiology

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Speciation and adaptive evolution reshape antioxidant enzymatic system diversity across the phylum Nematoda

BMC Biology

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Anisotropic ridge/groove microstructure for regulating morphology and biological function of Schwann cells

Applied Materials Today

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Comparison of neural stem/progenitor cells from adult Gecko japonicus and mouse spinal cords

Experimental Cell Research

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The Landscape of Gene Expression and Molecular Regulation Following Spinal Cord Hemisection in Rats

Frontiers in Molecular Neuroscience

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Gekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration.

Nature communications

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Different Astrocytic Activation between Adult Gekko japonicus and Rats during Wound Healing In Vitro.

PloS one

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Jian Yang